Modulation of the aqueous solubility and dissolution rate of Huperzine A through pharmaceutical co-crystals

Abstract

“Huperzine A is a naturally occurring alkaloid extracted from Chinese club moss, Huperzia serrata, or from any other Huperzia species, and is used in clinical trials to possible treat Alzheimer’s Disease because of its effects as an Acetyl cholinesterase Inhibitor (AChEI), which therefore leads to an improvement im memory function, thinking capabilities and thinking processes. Huperzine A is poorly soluble in water and thus the major goal from this proposed research is to modulate the aqueous solunility and dissolution rate of Huperzine A.”